Toothpaste and mouthwash contain many ingredients to enhance the quality and health benefits. Fluorine is added in typical amounts of 1000 to 1500 ppm to prevent cavities by strengthening tooth enamel. Active ingredients are often sodium fluoride (NaF), stannous fluoride (SnF2), or sodium monofluorophosphate (Na2PO3F). In addition to fluoride, other ingredients can be included to achieve whitening effects (peroxide) or abrasiveness (silica).
The fluorine amount has to be accurately controlled. A minimum level of 1000 ppm is needed to provide the desired benefit of strengthening tooth enamel, but exceedingly high fluorine amounts can possibly lead to health risks (dental fluorosis).
With Time Domain Nuclear Magnetic Resonance (TD-NMR), the fluorine content can be accurately measured irrespective of the fluorine compound and the toothpaste matrix.
The simplicity and the speed of the analysis make TD-NMR the method of choice for production, product development and quality control.