Implementation of USP <467> “Residual Solvents” using a GERSTEL MPS 2 based Headspace Autosampler

USP <467> Residual Solvents [1] is a general chapter in the US Pharmacopeia that describes a headspace gas chromatographic method for the determination of residual solvents in pharmaceutical products, active ingredients, and excipients. As originally written, it described parameters used with balanced-pressure or pressure loop based headspace instruments. Recent updates [2] have included parameters for syringe based systems.