Some of the key processes in the petrochemical industry are conversions of high-grade ethylene (C2) and propane/propylene (C3) feedstocks into end products (polyethylene, polypropylene) and intermediates such as 1-butene. These, of course, are the building blocks for plastics and a wide range of products, and are a large industry with 55 million metric tons of…
The analysis of Benzene, Toluene, Ethylbenzene, Xylenes, and Methyl-tert-butyl ether is a common analysis performed in many laboratories. BTEX compounds are naturally occurring constituents in crude oil and are created and used during the processing of refined petroleum products and during the production of chemical intermediates for many consumer products. BTEX compounds represent some of…
Several studies in the pharmaceutic industry validated the extremly valuable application of TD-NMR relaxometry in body composition analysis of mice and rats [1]. Instead of harmful treatment as in chemical analysis or in DEXA, the animal is brought only into magnetic fields comparable to well known clinical MRI, the analysis takes place in a few…
Toothpaste and mouthwash contain many ingredients to enhance the quality and health benefits. Fluorine is added in typical amounts of 1000 to 1500 ppm to prevent cavities by strengthening tooth enamel. Active ingredients are often sodium fluoride (NaF), stannous fluoride (SnF2), or sodium monofluorophosphate (Na2PO3F). In addition to fluoride, other ingredients can be included to…
In liposome and lipid nanoparticle (LNP) drug-delivery applications, particle size is a critical quality attribute (CQA) that impacts bioaccessibility, retention time and biodistribution. Microfluidization is a common method for largescale production of liposomes within a well-defined size range. The resulting particle size is dependent on a number of process parameters, such as chamber pressure and…
In metabolomics studies, large sample sets have to be analyzed to allow statistical differentiation of sample types.
In metabolomics studies, large sample sets have to be analyzed to allow statistical differentiation of sample types.
USP <467> Residual Solvents [1] is a general chapter in the US Pharmacopeia that describes a headspace gas chromatographic method for the determination of residual solvents in pharmaceutical products, active ingredients, and excipients.
This application note describes two automated methods for screening of extractable compounds from materials for food packaging, medical or technical purposes.
In this report, a completely automated, 96 well plate format “Prep-and-Shoot” workfl ow including enzymatic hydrolysis, dilution and injection is described.
IV bag components were analyzed for extractables using direct thermal desorption/thermal extraction combined with a unit mass resolution GC/MSD system.
The in vitro metabolic stability of potential drug candidates is routinely examined at an early stage of drug discovery.